Protein Homeostasis in Neurodegenerative Diseases


Protein aggregation is a hallmark of numerous neurodegenerative diseases including Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), and the polyglutamine diseases.  The Scaglione lab focuses on understanding how protein quality control pathways counteract protein aggregation to maintain neuronal health.



Dictyostelium discoideum have a unique proteome that contains ~10,000 homopolymeric amino acid repeats.  Among the most common repeats is glutamine, the amino acid repeat that causes a class of nine neurodegenerative diseases.  The Scaglione lab focuses on understanding how Dictyostelium's protein quality control network suppresses polyQ aggregation.


RECENT Scaglione Lab News

3/1/2018- Samantha Chou, a MSTP student joins the Scaglione lab, welcome Samantha!

1/2018- Congratulations to Adam Kanack and Oliver Newsom on their paper recently published in JBC!

1/2018- Welcome to Wojciech Jankiewicz, a rotating IDP stuents.

11/2017- Matt met with former Prime Minister David Cameron who came to MCW to discuss Alzheimer's disease.  

10/2017- Oliver has become the face of MCW.

10/2017- Welcome to Ashley Era, a rotating IDP student.

8/2017- Welcome to Madeline Brunner, a rotating IDP student.

7/2017- Congratulations to Mahmoud Abu Eid who is leaving the lab to attend graduate school at MCW.

7/2017- Congratulations to Katy LaFond who is leaving the lab to attend medical school at AUA.

6/2017- Welcome to Kelsey Meachum, a rotating MSTP student.

5/2017- Congrats to Stephanie Santarriaga on winning a best talk award at the recent MCW graduate student symposium.

5/2017- Welcome to Danielle Bauhan and Holly Haver, two new graduate students in the Scaglione lab!

4/2017- A new publication in Human Molecular Genetics in collaboration with the Todi lab. Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.

3/2017- Welcome to Holly Haver, a rotating IDP student

1/2017- Welcome to Darcy Kannack, a rotating IDP student

10/2016- Welcome to Thiago Arzua, a NDP rotation student




Protein degradation by the ubiquitin-proteasome system is one mechanism neurons utilize to clear aggregation prone proteins.  The Scaglione lab is interested in understanding the mechanism of ubiquitin transfer to allow development of methodolgies to   hi-jack the ubiquitination machinery.



10/2016- Welcome to Mahmoud AbuEid, a research technologist in the Scaglione lab.

10/2016- Welcome to Luke Christiansen, a first year IDP rotation student.

10/2016- Welcome to Katy LaFond a new research technologist in the Scaglione lab.

9/2016-  Congratulations to Adam Kanack on receiving the Peter G. Pentchev Fellowship from the National Piemann-Pick Disease Foundation!  Adam will be focusing on developing strategies to inhibit ubiquitination of NPC1.

8/2016- Welcome to Danielle Bauhan, a first year IDP rotating student

8/2016- Welcome to Seung-Yi Lee, a first year NDP rotating in the lab.

8/2016- Congratulations to Adam Knack on advancing to PhD candidacy!

8/2016- The Scaglione lab will be co-organizing the 2019 International Dictyostelium Conference.

8/2016- Stephanie Santarriaga gave a great talk at the International Dicyostelium Conference in Tucson AZ!

7/2016- Congrats to Stephanie Santarriaga who was awarded a F31 NRSA grant form NIH/NINDS!

7/2016- The Scaglione lab has been awarded a R35 Outstanding Investigator Award/MIRA from NIH/NIGMS!